Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.70 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390002 | 0.86 | MAPK14 (0.70) | MAPK14FFAR1FFAR4P2RX7MAPK1 | |
| SCHEMBL4476593 | 0.83 | MAPK14 (1.00) | MAPK14P2RX7MAPK1TDP1MAPT | |
| SCHEMBL4489354 | 0.77 | MAPK14 (0.70) | MAPK14FFAR1FFAR4P2RX7ALDH1A1 | |
| SCHEMBL4380170 | 0.77 | MAPK14 (0.77) | MAPK14MAPK1TDP1MAPTL3MBTL1 | |
| SCHEMBL3522684 | 0.72 | ALDH1A1 (0.48) | MAPK14P2RX7MAPK1TDP1ALDH1A1 | |
| SCHEMBL4376402 | 0.71 | MAPK14 (0.76) | MAPK14MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4488411 | 0.71 | MAPK14 (0.74) | MAPK14ALDH1A1KDM4EHPGD | |
| SCHEMBL6509223 | 0.70 | MAPK14 (0.64) | MAPK14ALDH1A1 | |
| SCHEMBL4381283 | 0.69 | MAPK14 (0.79) | MAPK14MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL18401064 | 0.69 | MAPK14 (0.64) | MAPK14FFAR4MAPK1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |