Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MYC | P01106 | 8/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390396 | 0.87 | ALDH1A1 (0.50) | ALDH1A1LMNAMYCMAPK14ROCK2 | |
| SCHEMBL4379220 | 0.81 | ALDH1A1 (0.50) | ALDH1A1LMNAMYCMAPK14ROCK2 | |
| SCHEMBL6646966 | 0.75 | MYC (0.51) | MYCMAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14189583 | 0.71 | ALDH1A1 (0.53) | ALDH1A1MYC | |
| SCHEMBL2706592 | 0.71 | MAPK14 (0.57) | ALDH1A1MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL12268010 | 0.70 | KDM4E (0.50) | ALDH1A1MAPK14TSHRCA12CA1 | |
| SCHEMBL15668584 | 0.70 | MYC (0.75) | ALDH1A1LMNAMYC | |
| SCHEMBL15714708 | 0.69 | MYC (0.60) | ALDH1A1LMNAMYC | |
| Hydrazine SCHEMBL15668725 | 0.69 | MYC (0.73) | ALDH1A1LMNAMYC | |
| SCHEMBL4377764 | 0.68 | ALDH1A1 (0.52) | ALDH1A1LMNAMYCTSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |