Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063692 | 0.83 | PDE3B (0.61) | PDE3BPDE3AKMT2AALDH1A1TSHR | |
| SCHEMBL11062559 | 0.83 | PDE3B (0.61) | PDE3BPDE3AKMT2AALDH1A1TSHR | |
| SCHEMBL3082182 | 0.83 | HRH3 (0.55) | PDE3BPDE3AKMT2AALDH1A1HRH3 | |
| SCHEMBL3087638 | 0.82 | HRH3 (0.56) | PDE3BPDE3AKMT2AALDH1A1HRH3 | |
| SCHEMBL11061133 | 0.81 | PDE3B (0.51) | PDE3BPDE3AKMT2AALDH1A1TSHR | |
| SCHEMBL11062211 | 0.81 | PDE3B (0.58) | PDE3BPDE3AKMT2AALDH1A1TSHR | |
| SCHEMBL3090707 | 0.79 | HRH3 (0.63) | PDE3BPDE3AHRH3RAB9ASMN1; SMN2 | |
| SCHEMBL11061345 | 0.77 | PDE3B (0.68) | PDE3BPDE3AKMT2AALDH1A1TSHR | |
| SCHEMBL3087404 | 0.74 | HRH3 (0.62) | HRH3CYP2D6 | |
| SCHEMBL13636473 | 0.74 | PDE3B (0.59) | PDE3BPDE3AKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |