Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.65 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | HRH2 | P25021 | 2/20 | 0.65 |
| ▸ | HRH1 | P35367 | 2/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.62 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132206 | 0.92 | SIGMAR1 (0.58) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL6132205 | 0.92 | SIGMAR1 (0.58) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL24183442 | 0.89 | SMN1; SMN2 (0.67) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL5103812 | 0.88 | CHRM1 (0.61) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL13661299 | 0.88 | SMN1; SMN2 (0.65) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL26103660 | 0.88 | SMN1; SMN2 (0.61) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL30738370 | 0.88 | SMN1; SMN2 (0.65) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL600547 | 0.88 | TMEM97 (0.56) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL14529024 | 0.88 | SMN1; SMN2 (0.68) | SIGMAR1TMEM97HRH3HTR1AHRH2 | |
| SCHEMBL14528537 | 0.87 | SMN1; SMN2 (0.64) | SIGMAR1TMEM97HRH3HTR1AHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | SIGMAR1 237/4885TMEM97 320/4885HRH3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.