Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | MC5R | P33032 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190906 | 0.85 | GPR183 (0.57) | DRD2DRD3GPR183POLBL3MBTL1 | |
| SCHEMBL4377287 | 0.85 | GPR183 (0.57) | DRD2DRD3GPR183POLBL3MBTL1 | |
| SCHEMBL13636345 | 0.77 | GPR183 (0.43) | DRD3GPR183HRH3POLBL3MBTL1 | |
| SCHEMBL6782618 | 0.67 | KMT2A (0.68) | GPR183POLBL3MBTL1MAPT | |
| SCHEMBL22110835 | 0.67 | HPGD (0.48) | GPR183POLBL3MBTL1MAPT | |
| SCHEMBL5573114 | 0.67 | MEN1 (0.53) | GPR183POLBL3MBTL1MAPT | |
| SCHEMBL5573122 | 0.67 | MEN1 (0.53) | GPR183POLBL3MBTL1MAPT | |
| SCHEMBL4377283 | 0.67 | HRH3 (0.50) | DRD2SLC6A4DRD3HRH3POLB | |
| SCHEMBL13636348 | 0.67 | GPR183 (0.55) | DRD2GPR183POLBL3MBTL1MAPT | |
| SCHEMBL4380701 | 0.67 | GPR183 (0.55) | DRD2GPR183POLBL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |