Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 4/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4383718 | 0.84 | GPR183 (0.62) | GPR183JUNNFKB1POLBALDH1A1 | |
| SCHEMBL14190907 | 0.84 | GPR183 (0.62) | GPR183JUNNFKB1POLBALDH1A1 | |
| SCHEMBL13636156 | 0.77 | DRD2 (0.45) | GPR183POLBL3MBTL1HRH3DRD3 | |
| SCHEMBL17131917 | 0.71 | THRB (0.64) | THRBPOLBALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL22110835 | 0.70 | HPGD (0.48) | GPR183POLBALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4375908 | 0.69 | NAMPT (0.59) | GPR183JUNNFKB1POLBALDH1A1 | |
| SCHEMBL14190899 | 0.69 | NAMPT (0.59) | GPR183JUNNFKB1POLBALDH1A1 | |
| SCHEMBL14190905 | 0.69 | GPR183 (0.67) | GPR183POLBALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4380512 | 0.69 | GPR183 (0.67) | GPR183POLBALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL13636191 | 0.68 | ALDH1A1 (0.68) | GPR183ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |