Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380655 | 0.83 | TRPV1 (0.54) | MGLLMEN1KMT2AALDH1A1HRH3 | |
| Hydrochloric Acid SCHEMBL4380652 | 0.82 | HRH3 (0.54) | MGLLMEN1KMT2AALDH1A1HRH3 | |
| SCHEMBL18753753 | 0.81 | ADORA2A (0.56) | MGLLLMNAMEN1POLBKMT2A | |
| SCHEMBL7383611 | 0.81 | GAA (0.62) | LMNAMEN1POLBKMT2AALDH1A1 | |
| SCHEMBL4389506 | 0.79 | HRH3 (0.51) | MGLLPOLBALDH1A1HRH3 | |
| SCHEMBL4384441 | 0.77 | HRH3 (0.57) | MGLLPOLBALDH1A1HRH3 | |
| SCHEMBL28786999 | 0.77 | LMNA (0.53) | MGLLLMNAMEN1KMT2ABCHE | |
| Hydrochloric Acid SCHEMBL4384439 | 0.76 | HRH3 (0.58) | MGLLPOLBALDH1A1HRH3 | |
| SCHEMBL4380496 | 0.74 | KMT2A (0.62) | MEN1KMT2AHRH3 | |
| SCHEMBL19562092 | 0.73 | ABL1 (0.47) | LMNAKMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |