Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GPR183 | P32249 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190955 | 0.82 | MAPT (0.59) | TDP1ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL4375431 | 0.82 | MAPT (0.59) | TDP1ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL4382910 | 0.71 | GPR183 (0.52) | TDP1ALDH1A1KMT2AGPR183KDM4E | |
| SCHEMBL13636500 | 0.71 | GPR183 (0.52) | TDP1ALDH1A1KMT2AGPR183KDM4E | |
| SCHEMBL4377423 | 0.71 | GPR183 (0.57) | TDP1ALDH1A1KMT2AGPR183MEN1 | |
| SCHEMBL13636161 | 0.71 | GPR183 (0.57) | TDP1ALDH1A1KMT2AGPR183MEN1 | |
| SCHEMBL4381758 | 0.69 | GPR183 (0.57) | TDP1ALDH1A1GPR183KDM4EL3MBTL1 | |
| SCHEMBL14190945 | 0.69 | GPR183 (0.57) | TDP1ALDH1A1GPR183KDM4EL3MBTL1 | |
| SCHEMBL28170710 | 0.67 | ALDH1A3 (0.62) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL14190904 | 0.67 | MAPT (0.62) | TDP1ALDH1A1KMT2AGPR183MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |