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Sugi Predict / Targets / ALDH1A3

ALDH1A3

Retinaldehyde dehydrogenase 3 · P47895 · ALDH1A3 on Sugi Atlas →

25,902 patent compounds predicted against ALDH1A3, 13,440 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL785129 SCHEMBL785129 0.67 15/20
SCHEMBL939933 SCHEMBL939933 0.64 15/20
SCHEMBL785387 SCHEMBL785387 0.57 12/20
SCHEMBL217646 SCHEMBL217646 0.64 10/20
SCHEMBL219877 SCHEMBL219877 0.63 10/20
SCHEMBL219585 SCHEMBL219585 0.61 10/20
SCHEMBL220441 SCHEMBL220441 0.59 9/20
SCHEMBL217845 SCHEMBL217845 0.58 9/20
SCHEMBL220148 SCHEMBL220148 0.57 9/20
SCHEMBL218890 SCHEMBL218890 0.56 9/20
SCHEMBL217061 SCHEMBL217061 0.45 9/20
SCHEMBL217633 SCHEMBL217633 0.60 8/20
SCHEMBL216921 SCHEMBL216921 0.56 8/20
SCHEMBL938243 SCHEMBL938243 0.38 8/20
SCHEMBL236991 SCHEMBL236991 0.66 7/20
SCHEMBL217206 SCHEMBL217206 0.54 7/20
SCHEMBL217636 SCHEMBL217636 0.43 7/20
SCHEMBL219931 SCHEMBL219931 0.41 7/20
SCHEMBL218777 SCHEMBL218777 0.40 7/20
SCHEMBL863332 SCHEMBL863332 0.63 6/20

Clinical trials — most relevant to ALDH1A3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Semaglutide and Vascular Regeneration PHASE4UNKNOWN
Disulfiram for Treatment of Retinal Degeneration PHASE1/PHASE2RECRUITING
Carboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients PHASE2UNKNOWN
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1) PHASE1/PHASE2RECRUITING
Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa PHASE2UNKNOWN
ADX-629 Therapy for Sjogren-Larsson Syndrome PHASE1/PHASE2COMPLETED
Metabolic Mapping to Measure Retinal Metabolism PHASE2COMPLETED
Evaluating a New Peptide Therapy for Retinal Diseases: AMD, Diabetic Retinopathy, and Dystrophies PHASE1/PHASE2RECRUITING
Scleral Buckling for Retinal Detachment Prevention in Genetically Confirmed Stickler Syndrome PHASE2WITHDRAWN
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa PHASE1COMPLETED
Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye PHASE1COMPLETED
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion nanNOT_YET_RECRUITING
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models nanCOMPLETED
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Natural History Study in Patients With PDE6A-, PDE6B- and RHO-linked Retinitis Pigmentosa nanACTIVE_NOT_RECRUITING
Genetic Association of Diabetic Retinopathy-1 nanUNKNOWN
Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial nanCOMPLETED
Bipolar Disorder With Alcoholism in Han Chinese nanUNKNOWN
Molecular Genetics of Retinal Degenerations nanCOMPLETED
Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa nanCOMPLETED
ADH1B and ALDH Gene Variants and Lung Cancer Risk nanNOT_YET_RECRUITING
Natural History Study of Inherited Retinal Diseases nanRECRUITING
Clinical and Genetic Analyzes of Age-related Macular Degeneration nanUNKNOWN
Biomarkers in Retinitis Pigmentosa nanUNKNOWN
Molecular Epidemiology of Parkinson's Disease nanCOMPLETED
Seven Year Update of Macular Degeneration Patients nanCOMPLETED
Alcohol Metabolism and Disease Risk in Asians nanCOMPLETED
Biomarkers In Retinitis Pigmentosa (BIRP) nanCOMPLETED
Genes Associated With Bronchopulmonary Dysplasia and Retinopathy of Prematurity nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ALDH1A3 binder may also engage these)

ProteinNameSimilarity
Q9JHW9 — 1.000 Q9JHW9 →
Q8K4D8 — 1.000 Q8K4D8 →
P51977 — 1.000 P51977 →
Q9CZS1 — 1.000 Q9CZS1 →
ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 1.000 landscape →
ALDH1A1 Aldehyde dehydrogenase 1A1 1.000 landscape →
Q2XQV4 — 1.000 Q2XQV4 →
P48644 — 1.000 P48644 →
P81178 — 1.000 P81178 →
Q8HYE4 — 0.999 Q8HYE4 →
P15437 — 0.999 P15437 →
Q25417 — 0.998 Q25417 →
Q9SU63 — 0.998 Q9SU63 →
P24549 — 0.996 P24549 →
Q62148 — 0.996 Q62148 →
Q29490 — 0.996 Q29490 →
Q63639 — 0.996 Q63639 →
Q8MI17 — 0.995 Q8MI17 →
Q28399 — 0.995 Q28399 →
P28237 — 0.995 P28237 →
P11884 — 0.995 P11884 →
P47738 — 0.995 P47738 →
Q84LK3 — 0.995 Q84LK3 →
P51647 — 0.995 P51647 →
Q9I8W8 — 0.995 Q9I8W8 →
Q5RF00 — 0.995 Q5RF00 →
O35945 — 0.994 O35945 →
P13601 — 0.994 P13601 →
Q56R04 — 0.994 Q56R04 →
P86886 — 0.994 P86886 →