Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190984 | 0.86 | HRH3 (0.61) | SMN1; SMN2HPGDGAAMAPTHRH3 | |
| Hydrochloric Acid SCHEMBL4375428 | 0.85 | HRH3 (0.62) | SMN1; SMN2HPGDGAAMAPTHRH3 | |
| SCHEMBL14525207 | 0.82 | HPGD (0.48) | SMN1; SMN2HPGDGAAMAPTHRH3 | |
| Hydrochloric Acid SCHEMBL4378373 | 0.81 | HPGD (0.47) | SMN1; SMN2HPGDGAAMAPTHRH3 | |
| SCHEMBL13636210 | 0.77 | HRH3 (0.49) | SMN1; SMN2HPGDGAAMAPTHRH3 | |
| SCHEMBL20750429 | 0.75 | CA12 (0.51) | SMN1; SMN2HPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL10244908 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDGAAMAPTHRH3 | |
| SCHEMBL16133049 | 0.74 | NPC1 (0.61) | SMN1; SMN2HPGDGAAMAPTKMT2A | |
| SCHEMBL6601332 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2HPGDGAAMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL4543073 | 0.69 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDGAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |