Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | HRH2 | P25021 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190973 | 0.85 | HRH3 (0.61) | HRH3HRH2HRH1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4388263 | 0.84 | HRH3 (0.62) | HRH3HRH2HRH1HPGDSMN1; SMN2 | |
| SCHEMBL13636381 | 0.82 | HRH3 (0.52) | HRH3HRH1SMN1; SMN2PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL4388621 | 0.81 | HRH3 (0.54) | HRH3HRH1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL13636245 | 0.77 | SMN1; SMN2 (0.49) | HRH3HRH2HRH1HPGDSMN1; SMN2 | |
| SCHEMBL7323131 | 0.74 | FKBP1A (0.61) | SMN1; SMN2GAAMAPTMEN1ALDH1A1 | |
| SCHEMBL18753913 | 0.74 | CA12 (0.54) | HRH3GAAALDH1A1KDM4E | |
| SCHEMBL20512382 | 0.69 | DRD2 (0.56) | HRH3HRH2HRH1SMN1; SMN2MAPT | |
| SCHEMBL15650734 | 0.69 | POLB (0.61) | SMN1; SMN2GAAMEN1ALDH1A1KMT2A | |
| SCHEMBL20750427 | 0.69 | CNR2 (0.51) | SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |