Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | CHKA | P35790 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | FABP6 | P51161 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1177194 | 0.99 | HRH3 (0.97) | HRH3HPGDCHKASMN1; SMN2USP2 | |
| SCHEMBL1014002 | 0.90 | HPGD (0.86) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL10184001 | 0.88 | HRH3 (0.78) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL1450838 | 0.87 | HRH3 (0.78) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL1177617 | 0.86 | HRH3 (0.75) | HRH3HPGDCHKASMN1; SMN2USP2 | |
| SCHEMBL3456205 | 0.86 | HPGD (1.00) | HRH3HPGDSMN1; SMN2USP2TSHR | |
| SCHEMBL13636488 | 0.86 | HRH3 (1.00) | HRH3HPGDCHKAPOLBFABP6 | |
| SCHEMBL521532 | 0.85 | HRH3 (1.00) | HRH3HPGD | |
| Hydrochloric Acid SCHEMBL1177198 | 0.84 | HRH3 (0.97) | HRH3HPGDCHKAPOLBFABP6 | |
| Hydrochloric Acid SCHEMBL1450562 | 0.84 | HRH3 (0.97) | HRH3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558595-B1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-25 | — | — | EP | disclosed |
| US-7414047-B2 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-7414047-B2 | Piperazinyl and diazapanyl benzamides and benzthioamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | disclosed |
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | APODACA RICHARD L | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080056991-A1 | PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES | HRH2, HNMT, HRH3 | HRH3 3/4885HPGD 384/4885CHKA 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.