Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247285 | 0.85 | HTT (0.58) | HPGDHTTALDH1A1LMNAGABRA1 | |
| SCHEMBL3533063 | 0.84 | HPGD (0.48) | HPGDHTTALDH1A1LMNAGABRA1 | |
| SCHEMBL7105508 | 0.81 | ALDH1A1 (0.41) | HPGDHTTALDH1A1LMNAPARP1 | |
| SCHEMBL502441 | 0.81 | ALDH1A1 (0.48) | HPGDHTTALDH1A1LMNAKDM4E | |
| SCHEMBL11419017 | 0.80 | PARP1 (0.47) | ALDH1A1PARP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30006284 | 0.77 | PARP1 (0.44) | ALDH1A1PARP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6175216 | 0.76 | SLC6A2 (0.57) | ALDH1A1PARP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10710591 | 0.75 | ALDH1A1 (0.41) | HPGDHTTALDH1A1LMNAPARP1 | |
| SCHEMBL28752739 | 0.75 | PARP1 (0.42) | ALDH1A1LMNAPARP1SLC6A2SLC6A4 | |
| SCHEMBL2555304 | 0.74 | ALDH1A1 (0.48) | ALDH1A1LMNAGABRA1GABRB2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242385-B1 | CYTOKINE, ESPECIALLY TNF-ALPHA, INHIBITORS | PHARMACOPEIA INC (US) | 2009-11-25 | — | — | EP | disclosed |