Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | ATM | Q13315 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910598 | 1.00 | GAA (0.52) | GAAKMT2AMEN1ATMNPSR1 | |
| SCHEMBL6562182 | 0.83 | GAA (0.46) | GAAKMT2AMEN1MAPTTHRB | |
| SCHEMBL6562185 | 0.83 | GAA (0.46) | GAAKMT2AMEN1MAPTTHRB | |
| SCHEMBL10947371 | 0.82 | GAA (0.49) | GAAKMT2AMEN1ATMNPSR1 | |
| SCHEMBL16563870 | 0.82 | ESR1 (0.54) | GAAKMT2AMEN1ATMNPSR1 | |
| SCHEMBL12741450 | 0.82 | ESR1 (0.54) | GAAKMT2AMEN1ATMNPSR1 | |
| SCHEMBL10874676 | 0.82 | ESR1 (0.54) | GAAKMT2AMEN1ATMNPSR1 | |
| SCHEMBL13035863 | 0.81 | GAA (0.56) | GAAKMT2AMEN1ATMMAPT | |
| SCHEMBL2777133 | 0.80 | GAA (0.50) | GAAKMT2AMEN1ATMLMNA | |
| SCHEMBL1546560 | 0.80 | GAA (0.50) | GAAKMT2AMEN1ATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |