Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777130 | 1.00 | GAA (0.50) | GAAMEN1KMT2ATRPA1ABCB11 | |
| SCHEMBL18944664 | 0.81 | ATM (0.42) | GAAMEN1KMT2ATRPA1ABCB11 | |
| SCHEMBL13636390 | 0.80 | GAA (0.52) | GAAMEN1KMT2AATMNPC1 | |
| SCHEMBL10874676 | 0.80 | ESR1 (0.54) | GAAMEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL16563870 | 0.80 | ESR1 (0.54) | GAAMEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL12741450 | 0.80 | ESR1 (0.54) | GAAMEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL8910598 | 0.80 | GAA (0.52) | GAAMEN1KMT2AATMNPC1 | |
| SCHEMBL11956601 | 0.78 | GAA (0.46) | GAAMEN1KMT2ATRPA1ABCB11 | |
| SCHEMBL1546559 | 0.78 | GAA (0.50) | GAAMEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL1546560 | 0.78 | GAA (0.50) | GAAMEN1KMT2AATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933240-B2 | Synthesis for thiazolidinedione compounds | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2015-01-13 | — | — | US | disclosed |
| CN-104011032-A | Heteroarylpiperidine and piperazine derivatives as fungicides | BAYER IP GMBH | 2014-08-27 | — | — | CN | disclosed |
| EP-2227475-B1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN INC (US) | 2014-02-19 | — | — | EP | disclosed |
| US-20130204008-A1 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2013-08-08 | — | — | US | disclosed |
| US-8269008-B2 | Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions | FIBROGEN, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100303928-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| CN-1128990-A | N-substituted azaheterocyclic carboxylic acids and esters thereof | NOVO NORDISK AS (DK) | 1996-08-14 | — | — | CN | disclosed |
| US-4032644-A | HYPOLIPIDEMIC AGENTS | SANDOZ, INC. (US) | 1977-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130204008-A1 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS | PPARG, PPARD, PPARA | GAA 3026/4885MEN1 4289/4885KMT2A 2472/4885 |
| US-20100303928-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | HIF1AN, HIF1A, EGLN2 | GAA 565/4885MEN1 4798/4885KMT2A 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.