Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL6033233 | 1.00 | MEN1 (0.50) | MEN1KMT2AIDO1RAB9ANPC1 | |
| SCHEMBL3443268 | 0.88 | IDO1 (0.58) | MEN1KMT2AIDO1RAB9ANPC1 | |
| Nitric Acid SCHEMBL3442027 | 0.86 | MEN1 (0.56) | MEN1KMT2AIDO1RAB9ANPC1 | |
| Nitric Acid SCHEMBL4467527 | 0.83 | SOS1 (0.34) | KMT2AIDO1RAB9AMAPTALDH1A1 | |
| Nitric Acid SCHEMBL7231544 | 0.83 | KMT2A (0.53) | MEN1KMT2ARAB9ANPC1TSHR | |
| Nitric Acid SCHEMBL2075832 | 0.83 | KMT2A (0.53) | MEN1KMT2ARAB9ANPC1TSHR | |
| Nitric Acid SCHEMBL2283510 | 0.81 | KMT2A (0.64) | MEN1KMT2AMAPTMAPK1ALDH1A1 | |
| Nitric Acid SCHEMBL3250036 | 0.81 | MEN1 (0.48) | MEN1KMT2AIDO1RAB9ANPC1 | |
| Nitric Acid SCHEMBL7234512 | 0.81 | MAPT (0.53) | MEN1KMT2AIDO1RAB9ANPC1 | |
| Nitric Acid SCHEMBL1880262 | 0.81 | CYP1A2 (0.54) | MEN1KMT2ARAB9AHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117106451-A | Low-damage semiconductor silicon etching solution, preparation method and application thereof | 浙江奥首材料科技有限公司 | 2023-11-24 | — | — | CN | claimed |
| CN-117106451-B | Low-damage semiconductor silicon etching solution, preparation method and application thereof | 浙江奥首材料科技有限公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-117106451-A | Low-damage semiconductor silicon etching solution, preparation method and application thereof | 浙江奥首材料科技有限公司 | 2023-11-24 | — | — | CN | disclosed |
| US-8067409-B2 | Protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| EP-2222682-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20090253723-A1 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-10-08 | — | — | US | disclosed |
| WO-2009070516-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-1187816-B1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | CELLTECH R&D LTD (GB) | 2006-12-20 | — | — | EP | disclosed |
| CN-1168721-C | 5-cyano-2-aminopyrimidine derivatives | О | 2004-09-29 | — | — | CN | disclosed |
| US-20040180914-A1 | 5-Cyano-2-aminopyrimidine derivatives | CELLTECH R&D LIMTIED | 2004-09-16 | — | — | US | disclosed |
| US-6579983-B1 | Potent and selective inhibitors of receptor tyrosine kinases involved in angiogenesis, especially KDR kinase and/or FGFr kinase | CELLTECH R&D LIMITED (GB) | 2003-06-17 | — | — | US | disclosed |
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2002-10-10 | — | — | US | disclosed |
| CN-1370152-A | 5-cyano-2-aminopyrimidine derivatives | CELLETECH CHIROSCIENCE LTD (GB) | 2002-09-18 | — | — | CN | disclosed |
| EP-1187816-A1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | Celltech R&D Limited (GB) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000078731-A1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | CELLTECH R&D LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253723-A1 | PROTEIN KINASE INHIBITORS | PACSIN2, MAP3K20, PHKG1 | MEN1 2427/4885KMT2A 2353/4885IDO1 4569/4885 |
| US-20040180914-A1 | 5-Cyano-2-aminopyrimidine derivatives | FLT1, FGFR1, KDR | MEN1 4739/4885KMT2A 2638/4885IDO1 682/4885 |
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | FLT1, FGFR1, KDR | MEN1 4769/4885KMT2A 2620/4885IDO1 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.