Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 9/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15607589 | 0.87 | NLRP3 (0.51) | NLRP3GLAFOLH1MAOBMEP1A | |
| SCHEMBL12522074 | 0.85 | NLRP3 (0.49) | NLRP3GLAFOLH1F10PRSS1 | |
| SCHEMBL6643724 | 0.85 | NLRP3 (0.49) | NLRP3GLAFOLH1F10PRSS1 | |
| SCHEMBL6643721 | 0.85 | NLRP3 (0.49) | NLRP3GLAFOLH1F10PRSS1 | |
| SCHEMBL5043134 | 0.82 | NLRP3 (0.53) | NLRP3GLAFOLH1MAOBMEP1A | |
| SCHEMBL19803700 | 0.79 | NLRP3 (0.53) | NLRP3GLAFOLH1MAOBMEP1A | |
| SCHEMBL2822759 | 0.78 | DPP7 (0.52) | NLRP3GLAFOLH1MAOBMEP1A | |
| SCHEMBL8954810 | 0.78 | DPP7 (0.52) | NLRP3GLAFOLH1MAOBMEP1A | |
| SCHEMBL6164203 | 0.78 | DPP7 (0.52) | NLRP3GLAFOLH1MAOBMEP1A | |
| SCHEMBL12521570 | 0.77 | F10 (0.71) | F10PRSS1F2PLGTMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931060-B1 | SUBSTITUTED N- (AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL PROPYL AMIDES | AVENTIS PHARMA INC (US) | 2009-11-25 | — | — | EP | disclosed |