NLRP3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL391522	0.67	11/20
SCHEMBL127182	0.58	11/20
SCHEMBL343805	0.43	8/20
SCHEMBL441932	0.58	6/20
SCHEMBL108018	0.50	5/20
Metalaxyl (SCHEMBL20990)	0.39	5/20
Mefenoxam (SCHEMBL22529)	0.39	5/20
Metalaxyl (SCHEMBL55820)	0.39	5/20
Metalaxyl (SCHEMBL156622)	0.38	5/20
Metalaxyl (SCHEMBL245477)	0.37	5/20
Glyburide (SCHEMBL22009)	1.00	4/20
SCHEMBL439465	0.58	4/20
SCHEMBL216157	0.42	4/20
SCHEMBL469817	0.39	4/20
Meglitinide (SCHEMBL37926)	0.71	3/20
SCHEMBL330382	0.51	3/20
SCHEMBL216958	0.50	3/20
SCHEMBL44737	0.47	3/20
SCHEMBL405771	0.46	3/20
SCHEMBL34240	0.45	3/20

Clinical trials — most relevant to NLRP3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardiotoxicity in Breast Cancer Patients	PHASE4	RECRUITING
The Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate	PHASE4	NOT_YET_RECRUITING
Colchicine for Symptom and Inflammation in Knee Osteoarthritis	PHASE2/PHASE3	COMPLETED
Impact of Colchicine and Low-dose Naltrexone on COVID-19	PHASE2	COMPLETED
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity	PHASE2	COMPLETED
The Açaí Berry COVID-19 Anti-Inflammation Trial	PHASE2	UNKNOWN
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ZYIL1 Following Oral Administration in Healthy Volunteers	PHASE1	COMPLETED
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery	nan	WITHDRAWN
Nucleotide Protein -3 in Epileptic Children	nan	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Effect of Low Dose of Colchicine on Platelet Reactivity	nan	COMPLETED
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk	nan	WITHDRAWN
Gluten-related Disorders in Familial Mediterranean Fever Patients	nan	COMPLETED
Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis	nan	SUSPENDED
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry Bad Cholesterol in the Blood	nan	COMPLETED
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
Extremes of Coronary Artery Disease and Normality:CAD Extremes	nan	RECRUITING
(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis	nan	UNKNOWN
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients	nan	ACTIVE_NOT_RECRUITING
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a NLRP3 binder may also engage these)

Protein	Name	Similarity
B0FPE9	—	1.000	B0FPE9 →
D4A523	—	1.000	D4A523 →
Q8R4B8	—	1.000	Q8R4B8 →
A6QLE5	—	1.000	A6QLE5 →
Q7RTR0	—	0.998	Q7RTR0 →
Q96MN2	—	0.998	Q96MN2 →
Q86W24	—	0.997	Q86W24 →
P59046	—	0.997	P59046 →
Q288C4	—	0.996	Q288C4 →
Q8WX94	—	0.995	Q8WX94 →
Q2LKU9	—	0.994	Q2LKU9 →
Q8BU40	—	0.991	Q8BU40 →
E9Q5R7	—	0.990	E9Q5R7 →
D9I2G1	—	0.990	D9I2G1 →
Q9R1M5	—	0.989	Q9R1M5 →
Q3TKR3	—	0.988	Q3TKR3 →
Q2LKV5	—	0.988	Q2LKV5 →
P59047	—	0.988	P59047 →
D9I2G4	—	0.988	D9I2G4 →
Q6B966	—	0.988	Q6B966 →
Q9NX02	—	0.987	Q9NX02 →
Q86W26	—	0.987	Q86W26 →
Q86W28	—	0.987	Q86W28 →
Q0GKD5	—	0.987	Q0GKD5 →
D9I2G3	—	0.986	D9I2G3 →
D9I2H0	—	0.986	D9I2H0 →
Q2LKW6	—	0.985	Q2LKW6 →
Q86W25	—	0.984	Q86W25 →
Q66X03	—	0.984	Q66X03 →
A1Z198	—	0.984	A1Z198 →