Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522454 | 0.79 | MMP2 (0.40) | MMP2TLR4CYP19A1PGRNR3C2 | |
| SCHEMBL14860552 | 0.73 | MMP2 (0.49) | MMP2TLR4CYP19A1PGRNR3C2 | |
| SCHEMBL12179749 | 0.62 | MMP2 (0.44) | MMP2CYP19A1PGRNR3C2AR | |
| SCHEMBL12162331 | 0.61 | MMP2 (0.44) | MMP2CYP19A1PGRNR3C2AR | |
| SCHEMBL14880036 | 0.61 | MMP2 (0.38) | MMP2TLR4CYP19A1AR | |
| SCHEMBL20231834 | 0.60 | AR (0.34) | TLR4CYP19A1PGRNR3C2AR | |
| SCHEMBL11181948 | 0.60 | TLR4 (0.47) | MMP2TLR4CYP19A1AR | |
| SCHEMBL5201714 | 0.59 | TLR4 (0.55) | MMP2TLR4CYP19A1 | |
| SCHEMBL14401277 | 0.59 | TLR4 (0.50) | MMP2TLR4 | |
| SCHEMBL10485863 | 0.58 | MMP2 (0.41) | MMP2CYP19A1PGRNR3C2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1591437-B1 | Interleukin-1 and tumor necrosis factor-alpha modulators, syntheses of said modulators and methods of using said modulators | NEREUS PHARMACEUTICALS INC (US) | 2009-11-25 | — | — | EP | disclosed |