Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946102 | 0.81 | HPGD (0.41) | HDAC1HDAC6DHODHFDPSIRAK4 | |
| SCHEMBL1811574 | 0.69 | CYP1A2 (0.45) | MKNK2HDAC1HDAC6CYP3A4CYP2C9 | |
| SCHEMBL7771674 | 0.67 | FDPS (0.44) | MKNK2HDAC1HDAC6CYP3A4CYP2C9 | |
| SCHEMBL27560848 | 0.67 | CYP1A2 (0.41) | MKNK2CYP3A4CYP2C9CYP2C19FDPS | |
| SCHEMBL17815611 | 0.66 | CFTR (0.49) | MKNK2HDAC1HDAC6FDPS | |
| SCHEMBL8411937 | 0.65 | FDPS (0.40) | MKNK2HDAC1HDAC6CYP3A4CYP2C9 | |
| SCHEMBL28204981 | 0.65 | POLB (0.43) | MKNK2HDAC1HDAC6CYP3A4CYP2C9 | |
| SCHEMBL3697841 | 0.65 | MKNK2 (0.49) | MKNK2HDAC1HDAC6CYP3A4CYP2C9 | |
| SCHEMBL680855 | 0.64 | FGFR1 (0.56) | MKNK2CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL28763050 | 0.64 | FDPS (0.46) | MKNK2HDAC1HDAC6CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137081-A2 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-11-12 | — | — | WO | disclosed |