Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958911 | 0.93 | HSD11B1 (0.75) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL958912 | 0.93 | HSD11B1 (0.75) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL958913 | 0.93 | HSD11B1 (0.75) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL957135 | 0.93 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL957133 | 0.93 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL957131 | 0.93 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL13953698 | 0.84 | HSD11B1 (0.71) | HSD11B1CYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL960169 | 0.83 | HSD11B1 (0.78) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL960167 | 0.83 | HSD11B1 (0.78) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL958193 | 0.83 | HSD11B1 (0.90) | HSD11B1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134392-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |