Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | TEK | Q02763 | 4/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13418901 | 1.00 | TP53 (1.00) | TP53ADRA2APLK1KDRTEK | |
| SCHEMBL13637360 | 1.00 | TP53 (1.00) | TP53ADRA2APLK1KDRTEK | |
| SCHEMBL12608668 | 0.90 | TP53 (0.82) | TP53ADRA2APLK1KDRTEK | |
| SCHEMBL12608669 | 0.90 | TP53 (0.82) | TP53ADRA2APLK1KDRTEK | |
| SCHEMBL13418930 | 0.86 | TP53 (0.76) | TP53ADRA2APLK1CHRNB2CHRNA5 | |
| SCHEMBL12608716 | 0.86 | TP53 (0.76) | TP53ADRA2APLK1CHRNB2CHRNA5 | |
| SCHEMBL18975402 | 0.85 | TP53 (0.74) | TP53ADRA2APLK1 | |
| SCHEMBL18969209 | 0.85 | TP53 (0.74) | TP53ADRA2APLK1 | |
| SCHEMBL14548900 | 0.84 | TP53 (0.73) | TP53ADRA2APLK1 | |
| SCHEMBL2365560 | 0.84 | TP53 (0.73) | TP53ADRA2APLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294186-B1 | INDUCING CELL DEATH BY INHIBITING ADAPTIVE HEAT SHOCK RESPONSE | INCURON INC (US) | 2019-10-09 | — | — | EP | disclosed |
| US-20190082845-A1 | CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS | INCURON INC (US) | 2019-03-21 | — | — | US | disclosed |
| US-9566265-B2 | Carbazole compounds and therapeutic uses of the compounds | INCURON, LLC (US) | 2017-02-14 | — | — | US | disclosed |
| US-8486697-B2 | Inducing cell death by inhibiting adaptive heat shock response | INCURON, LLC (US) | 2013-07-16 | — | — | US | disclosed |
| US-8486697-B2 | Inducing cell death by inhibiting adaptive heat shock response | INCURON, LLC (US) | 2013-07-16 | — | — | US | disclosed |
| WO-2009143290-A2 | INDUCING CELL DEATH BY INHIBITING ADAPTIVE HEAT SHOCK RESPONSE | CLEVELAND BIOLABS, INC (US) | 2009-11-26 | — | — | WO | disclosed |