Sugi Predict

Sugi Predict / Compounds / SCHEMBL12608669

SCHEMBL12608669

SCHEMBL12608669

C=C1CCc2c1ccc1c2c2cc(C(C)=O)ccc2n1CC[C@@H]1CCCN1C

nearest known ligand 0.82

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 1/20 0.82
▸ ADRA2A P08913 1/20 0.42
▸ PLK1 P53350 1/20 0.35
▸ KDR P35968 4/20 0.35
▸ TEK Q02763 4/20 0.35
▸ MAPT P10636 1/20 0.34
▸ HRH3 Q9Y5N1 1/20 0.34
▸ CHRNB2 P17787 2/20 0.33
▸ CHRNA7 P36544 2/20 0.33
▸ CHRNA4 P43681 2/20 0.33
▸ CHRNA5 P30532 1/20 0.33
▸ CNR1 P21554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12608668 1.00 TP53 (0.82) TP53ADRA2APLK1KDRTEK
SCHEMBL13637166 0.90 TP53 (1.00) TP53ADRA2APLK1KDRTEK
SCHEMBL13418901 0.90 TP53 (1.00) TP53ADRA2APLK1KDRTEK
SCHEMBL13637360 0.90 TP53 (1.00) TP53ADRA2APLK1KDRTEK
SCHEMBL15848980 0.88 TP53 (0.63) TP53ADRA2APLK1
SCHEMBL18500521 0.83 TP53 (0.71) TP53ADRA2APLK1HRH3CHRNB2
SCHEMBL12608655 0.83 TP53 (0.71) TP53ADRA2APLK1HRH3CHRNB2
SCHEMBL18500469 0.83 TP53 (0.71) TP53ADRA2APLK1HRH3CHRNB2
SCHEMBL18328986 0.82 TP53 (0.55) TP53KDRTEKMAPT
SCHEMBL18329004 0.81 TP53 (0.53) TP53KDRTEK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2017-06-15 — — US disclosed
US-9566265-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2017-02-14 — — US disclosed
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2015-12-03 — — US disclosed
US-9108916-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2015-08-18 — — US disclosed
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, LLC (US) 2014-10-09 — — US disclosed
US-8765738-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2014-07-01 — — US disclosed
US-8486697-B2 Inducing cell death by inhibiting adaptive heat shock response INCURON, LLC (US) 2013-07-16 — — US disclosed
US-20110124104-A1 INDUCING CELL DEATH BY INHIBITING ADAPTIVE HEAT SHOCK RESPONSE INCURON, INC. 2011-05-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885ADRA2A 3619/4885PLK1 2231/4885
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885ADRA2A 3619/4885PLK1 2231/4885
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885ADRA2A 3619/4885PLK1 2231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.