Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637207 | 0.99 | KMT2A (0.50) | MEN1KMT2ATSHRHPGDKDM4E | |
| SCHEMBL13637198 | 0.97 | KMT2A (0.47) | MEN1KMT2ATSHRHPGDKDM4E | |
| SCHEMBL13637201 | 0.95 | KMT2A (0.44) | MEN1KMT2ATSHRHPGDKDM4E | |
| SCHEMBL13441644 | 0.83 | PPARA (0.42) | KMT2AHPGDKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3593824 | 0.81 | PPARG (0.51) | HPGDKDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3576162 | 0.80 | LTB4R (0.48) | HPGDKDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3579483 | 0.77 | KDM4E (0.47) | KMT2AHPGDKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3587069 | 0.77 | KDM4E (0.46) | KMT2AHPGDKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3587335 | 0.77 | KDM4E (0.46) | MEN1KMT2AHPGDKDM4EALDH1A1 | |
| SCHEMBL3581610 | 0.77 | KDM4E (0.45) | HPGDKDM4EALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |