Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | PPARD | Q03181 | 4/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440568 | 0.92 | KDM4E (0.52) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL3577071 | 0.90 | LTB4R (0.50) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL13407823 | 0.90 | NPC1 (0.60) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL13637208 | 0.89 | LTB4R (0.44) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL3576162 | 0.88 | LTB4R (0.48) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL3586956 | 0.88 | KDM4E (0.44) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL13442151 | 0.85 | KDM4E (0.42) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL3587335 | 0.84 | KDM4E (0.46) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL13637206 | 0.82 | LTB4R (0.45) | LTB4RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL3581379 | 0.82 | FFAR1 (0.42) | LTB4RKDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |