Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.67 |
| ▸ | ABL1 | P00519 | 5/20 | 0.67 |
| ▸ | SRC | P12931 | 5/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.67 |
| ▸ | EGFR | P00533 | 3/20 | 0.67 |
| ▸ | FYN | P06241 | 3/20 | 0.67 |
| ▸ | YES1 | P07947 | 3/20 | 0.67 |
| ▸ | LYN | P07948 | 3/20 | 0.67 |
| ▸ | HCK | P08631 | 3/20 | 0.67 |
| ▸ | KIT | P10721 | 3/20 | 0.67 |
| ▸ | BCR | P11274 | 3/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.67 |
| ▸ | FGR | P09769 | 2/20 | 0.67 |
| ▸ | JAK3 | P52333 | 2/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.67 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14217761 | 0.91 | LCK (0.66) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL773009 | 0.85 | LCK (0.70) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL12702968 | 0.85 | LCK (0.77) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL20633186 | 0.84 | LCK (0.86) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL20633284 | 0.82 | LCK (0.76) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL12703008 | 0.82 | LCK (0.85) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL14153376 | 0.81 | ABL1 (0.83) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL8217094 | 0.80 | LCK (0.82) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL774220 | 0.80 | LCK (1.00) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL31060141 | 0.80 | LCK (1.00) | LCKABL1SRCMAPK14EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622473-B2 | 'N-(2-chloro-6-methylphenyl)-2-[[(6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-24 | — | — | US | disclosed |