Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.66 |
| ▸ | ABL1 | P00519 | 5/20 | 0.66 |
| ▸ | SRC | P12931 | 5/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.66 |
| ▸ | FYN | P06241 | 3/20 | 0.66 |
| ▸ | YES1 | P07947 | 3/20 | 0.66 |
| ▸ | LYN | P07948 | 3/20 | 0.66 |
| ▸ | HCK | P08631 | 3/20 | 0.66 |
| ▸ | KIT | P10721 | 3/20 | 0.66 |
| ▸ | BCR | P11274 | 3/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.66 |
| ▸ | FGR | P09769 | 2/20 | 0.66 |
| ▸ | JAK3 | P52333 | 2/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL773009 | 0.94 | LCK (0.70) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL13637396 | 0.91 | LCK (0.67) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL8217094 | 0.89 | LCK (0.82) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL12702968 | 0.84 | LCK (0.77) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL20633186 | 0.83 | LCK (0.86) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL12703008 | 0.82 | LCK (0.85) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL20633284 | 0.82 | LCK (0.76) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL774555 | 0.80 | LCK (0.72) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL14153376 | 0.80 | ABL1 (0.83) | LCKABL1SRCMAPK14EGFR | |
| SCHEMBL16785700 | 0.80 | LCK (0.70) | LCKABL1SRCMAPK14EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125440-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125440-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | LCK, ABL1, SRC | LCK 1/4885ABL1 2/4885SRC 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.