Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358781 | 0.82 | PDE5A (0.48) | MEN1KMT2ALMNAMAPTKDM4E | |
| SCHEMBL8241387 | 0.79 | CHRNB4 (0.50) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5185836 | 0.78 | MAPT (0.39) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3574928 | 0.77 | GRM5 (0.49) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL31259513 | 0.77 | — | — | |
| SCHEMBL178392 | 0.77 | — | — | |
| SCHEMBL2485359 | 0.76 | RAB9A (0.75) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6044323 | 0.76 | GAA (0.67) | NPC1SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL8241004 | 0.75 | NPC1 (0.49) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8502625 | 0.74 | KMT2A (0.39) | KMT2ANPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622490-B2 | especially for multi-drug resistant strains | TIBOTEC PHARMACEUTICALS, LTD. (IE) | 2009-11-24 | — | — | US | disclosed |