Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15664157 | 0.92 | MEN1 (0.38) | MEN1CYP2D6KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL3409038 | 0.90 | MEN1 (0.37) | MEN1CYP2D6KMT2A | |
| Hydrochloric Acid SCHEMBL4104974 | 0.90 | MEN1 (0.37) | MEN1CYP2D6KMT2A | |
| SCHEMBL18086595 | 0.84 | OGFRL1 (0.38) | — | |
| SCHEMBL17389314 | 0.84 | OGFRL1 (0.38) | — | |
| SCHEMBL3046521 | 0.84 | OGFRL1 (0.38) | — | |
| SCHEMBL16743560 | 0.84 | OGFRL1 (0.38) | — | |
| SCHEMBL15847181 | 0.84 | OGFRL1 (0.38) | — | |
| SCHEMBL12436681 | 0.84 | OGFRL1 (0.38) | — | |
| SCHEMBL24065040 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612085-B2 | Sigma 2 receptor ligands and therapeutic uses therefor | WASHINGTON UNIVERSITY (US) | 2009-11-03 | — | — | US | disclosed |
| US-20080161343-A1 | Sigma 2 Receptor Ligands and Therapeutic Uses Therefor | WASHINGTON UNIVERSITY | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161343-A1 | Sigma 2 Receptor Ligands and Therapeutic Uses Therefor | SIGMAR1, TMEM97, BAD | MEN1 4512/4885CYP2D6 1323/4885KMT2A 2434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.