Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 11/20 | 0.35 |
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922542 | 0.92 | P2RY12 (0.47) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL13638645 | 0.90 | P2RY12 (0.43) | P2RY12FBP1MEN1KMT2AS1PR4 | |
| SCHEMBL12177098 | 0.85 | P2RY12 (0.34) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL12177095 | 0.84 | P2RY12 (0.34) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL9922540 | 0.84 | P2RY12 (0.48) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL12177099 | 0.83 | P2RY12 (0.34) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL14113585 | 0.82 | P2RY12 (0.47) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL12177100 | 0.82 | WEE1 (0.34) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL9922131 | 0.82 | P2RY12 (0.54) | P2RY12FBP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9922303 | 0.82 | P2RY12 (0.46) | P2RY12FBP1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |