Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | FBP1 | P09467 | 5/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922131 | 0.91 | P2RY12 (0.54) | P2RY12ESR1ESR2FBP1ATM | |
| SCHEMBL13638374 | 0.90 | P2RY12 (0.39) | P2RY12FBP1SMN1; SMN2MEN1S1PR4 | |
| SCHEMBL14228576 | 0.87 | P2RY12 (0.49) | P2RY12ATMLMNATP53PPARG | |
| SCHEMBL13638371 | 0.84 | P2RY12 (0.38) | P2RY12ESR1ESR2ATMSMN1; SMN2 | |
| SCHEMBL14228643 | 0.83 | PPARG (0.41) | P2RY12ESR1ESR2ATMRAB9A | |
| SCHEMBL12177640 | 0.83 | ESR1 (0.39) | P2RY12ESR1ESR2ATMSMN1; SMN2 | |
| SCHEMBL13638370 | 0.83 | P2RY12 (0.38) | P2RY12ESR1ESR2ATMSMN1; SMN2 | |
| SCHEMBL9922130 | 0.82 | P2RY12 (0.55) | P2RY12ESR1ESR2FBP1SMN1; SMN2 | |
| SCHEMBL13638369 | 0.82 | ESR1 (0.38) | P2RY12ESR1ESR2ATMSMN1; SMN2 | |
| SCHEMBL13638647 | 0.82 | P2RY12 (0.39) | P2RY12ESR1ESR2ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |