Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 13/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638474 | 0.92 | AKT3 (0.50) | AKT3HDAC1TECTXKBTK | |
| SCHEMBL3477527 | 0.89 | AKT3 (0.68) | AKT3HDAC1GAARAB9A | |
| SCHEMBL13638295 | 0.85 | AKT3 (0.38) | AKT3GAATECTXKBTK | |
| SCHEMBL13638465 | 0.85 | HPGDS (0.47) | AKT3TECTXKBTKITK | |
| SCHEMBL13638504 | 0.84 | AKT3 (0.48) | AKT3GAATECTXKBTK | |
| SCHEMBL13638565 | 0.84 | AKT3 (0.48) | AKT3GAATECTXKBTK | |
| SCHEMBL14612850 | 0.82 | AKT3 (0.37) | AKT3TECTXKBTKITK | |
| SCHEMBL13638430 | 0.81 | AKT3 (0.36) | AKT3 | |
| SCHEMBL13638669 | 0.81 | CDK2 (0.36) | AKT3TECTXKBTKITK | |
| SCHEMBL13638569 | 0.80 | AKT3 (0.37) | AKT3TECTXKBTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615562-B2 | Such as 2-methyl-4-{5-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-butan-2-ol; tumor necrosis factor inhibitors; immunosuppressants; antiinflammatory agents | NOVARTIS AG (CH) | 2009-11-10 | — | — | US | disclosed |