Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177299 | 0.94 | EPHX2 (0.41) | EPHX2SHMT2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12177253 | 0.92 | EPHX2 (0.46) | EPHX2SHMT2 | |
| SCHEMBL12177178 | 0.90 | EPHX2 (0.43) | EPHX2SHMT2GBA1RXFP1POLB | |
| SCHEMBL9922427 | 0.88 | EPHX2 (0.42) | EPHX2SMN1; SMN2MEN1KMT2ACNR1 | |
| SCHEMBL13638503 | 0.88 | P2RY12 (0.39) | EPHX2CNR1 | |
| SCHEMBL12177281 | 0.86 | EPHX2 (0.43) | EPHX2SMN1; SMN2 | |
| SCHEMBL9922814 | 0.86 | EPHX2 (0.46) | EPHX2SMN1; SMN2MEN1KMT2ACNR1 | |
| SCHEMBL12177207 | 0.84 | EPHX2 (0.41) | EPHX2POLBCNR1 | |
| SCHEMBL9922261 | 0.83 | EPHX2 (0.43) | EPHX2SMN1; SMN2MEN1KMT2ACNR1 | |
| SCHEMBL9922193 | 0.83 | EPHX2 (0.47) | EPHX2RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |