Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922429 | 0.95 | P2RY12 (0.40) | P2RY12EPHX2PSEN1PSEN2APH1B | |
| SCHEMBL12177299 | 0.94 | EPHX2 (0.41) | P2RY12EPHX2PSEN1PSEN2APH1B | |
| SCHEMBL9922806 | 0.92 | EPHX2 (0.44) | P2RY12EPHX2PSEN1PSEN2APH1B | |
| SCHEMBL9922264 | 0.90 | P2RY12 (0.45) | P2RY12EPHX2PSEN1PSEN2APH1B | |
| SCHEMBL9922427 | 0.89 | EPHX2 (0.42) | P2RY12EPHX2PSEN1PSEN2APH1B | |
| SCHEMBL12177071 | 0.89 | P2RY12 (0.41) | P2RY12PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13638498 | 0.88 | EPHX2 (0.39) | EPHX2CNR1 | |
| SCHEMBL9923110 | 0.87 | P2RY12 (0.38) | P2RY12EPHX2PSEN1PSEN2APH1B | |
| SCHEMBL9922814 | 0.86 | EPHX2 (0.46) | P2RY12EPHX2PSEN1PSEN2APH1B | |
| SCHEMBL12177281 | 0.85 | EPHX2 (0.43) | P2RY12EPHX2EGFRHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |