Sugi Predict

Sugi Predict / Targets / FBP1

FBP1

Fructose-1,6-bisphosphatase 1 · P09467 · FBP1 on Sugi Atlas →

63,141 patent compounds predicted against FBP1, 41,512 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
(2-Nitrovinyl)Benzene (2-Nitrovinyl)Benzene (SCHEMBL30590) 1.00 16/20
(2-Nitrovinyl)Benzene (2-Nitrovinyl)Benzene (SCHEMBL30591) 1.00 16/20
SCHEMBL191350 SCHEMBL191350 1.00 15/20
SCHEMBL102629 SCHEMBL102629 1.00 13/20
SCHEMBL102630 SCHEMBL102630 1.00 13/20
SCHEMBL198569 SCHEMBL198569 0.47 13/20
SCHEMBL184964 SCHEMBL184964 0.72 12/20
SCHEMBL22181 SCHEMBL22181 0.60 11/20
SCHEMBL198547 SCHEMBL198547 0.57 11/20
SCHEMBL6729 SCHEMBL6729 0.52 11/20
SCHEMBL205355 SCHEMBL205355 1.00 10/20
SCHEMBL205356 SCHEMBL205356 1.00 10/20
SCHEMBL197882 SCHEMBL197882 0.60 9/20
SCHEMBL136546 SCHEMBL136546 0.51 9/20
SCHEMBL197217 SCHEMBL197217 0.49 9/20
SCHEMBL171036 SCHEMBL171036 0.49 9/20
SCHEMBL205715 SCHEMBL205715 0.65 8/20
SCHEMBL205716 SCHEMBL205716 0.65 8/20
SCHEMBL128635 SCHEMBL128635 0.61 8/20
SCHEMBL92035 SCHEMBL92035 0.43 8/20

Clinical trials — most relevant to FBP1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety, Efficacy Evaluation of Empagliflozin Administration for Neutropenia in Glycogenosis Type 1b and G6PC3 Deficiency PHASE2UNKNOWN
Dynamic PET/CT Evaluated the Response of Neoadjuvant Anti-PD1 Combination With Chemotherapy for Ⅱa-Ⅲb NSCLC PHASE2UNKNOWN
Metabolic Response of Slow Released Carbohydrates in Diabetes Mellitus PHASE1/PHASE2COMPLETED
Ketohexokinase Inhibition in NAFLD PHASE2COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
18F-FDS PET/CT in Healthy Volunteers and Patients With Suspected Infection EARLY_PHASE1UNKNOWN
Effect of Acute Fructose Load in Human nanCOMPLETED
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN
The Role of Sugars in Fat Accumulation in the Liver nanRECRUITING
Fructose and Glucose and TAS1R2 in Type 1 Diabetes nanCOMPLETED
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting. nanNOT_YET_RECRUITING
Family Blood Pressure Program - GENOA nanCOMPLETED
Family Blood Pressure Program - HyperGEN nanCOMPLETED
Family Blood Pressure Program - SAPPHIRe Network nanCOMPLETED
Genetic-specific Effects of Fructose on Liver Lipogenesis nanCOMPLETED
Fructose Supplementation in Carriers for Hereditary Fructose Intolerance nanCOMPLETED
Dual PETOvac - Dual Time PET/CT in the Preoperative Assessment of Ovarian Cancer nanUNKNOWN
Circadian Brown Adipose Tissue Metabolism nanCOMPLETED
Genome Scan for Obesity in a Multi-Ethnic Sample nanCOMPLETED
Plasma Mannose Associated Parameter Levels in Nondiabetic Coronary Artery Disease nanCOMPLETED
Diagnostic Significance of Single Center, Open and Prospective Evaluation of 18F-FDG PET/CT Dynamic Imaging and Genomic Sequencing in Detecting Metastatic Lesions and Differentiating Multiple Primary Lung Cancer From Intrapulmonary Metastases of Non-small Cell Lung Cancer nanUNKNOWN
18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology nanCOMPLETED
Evaluation of Blood Protein O-GlcNAcylation Levels in Children nanRECRUITING
Early Versus Late FDG-PET/CT in Bladder Cancer nanCOMPLETED
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes nanCOMPLETED
Effect Dietary Fructose on Fructose Kinetics in Type 2 Diabetes nanUNKNOWN
Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance? nanCOMPLETED
Family Blood Pressure Program - GenNet Network nanCOMPLETED
Clinical Utility of Breath Tests in GI nanCOMPLETED
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a FBP1 binder may also engage these)

ProteinNameSimilarity
Q9QXD6 — 1.000 Q9QXD6 →
P00637 — 1.000 P00637 →
P00636 — 1.000 P00636 →
P14766 — 1.000 P14766 →
Q0JHF8 — 0.999 Q0JHF8 →
O00757 — 0.998 O00757 →
P19112 — 0.997 P19112 →
Q2NW44 — 0.996 Q2NW44 →
Q8XCF0 — 0.996 Q8XCF0 →
A1TN89 — 0.996 A1TN89 →
Q9SDL8 — 0.996 Q9SDL8 →
Q42649 — 0.996 Q42649 →
P46276 — 0.996 P46276 →
Q1R324 — 0.996 Q1R324 →
Q31TG8 — 0.996 Q31TG8 →
B5F3E2 — 0.995 B5F3E2 →
B1JXN8 — 0.995 B1JXN8 →
Q2KJJ9 — 0.995 Q2KJJ9 →
Q3SZB7 — 0.994 Q3SZB7 →
Q9XF47 — 0.994 Q9XF47 →
Q3KJG0 — 0.994 Q3KJG0 →
B3E2M3 — 0.994 B3E2M3 →
A4W5X6 — 0.994 A4W5X6 →
A7MM48 — 0.993 A7MM48 →
A2WXB2 — 0.993 A2WXB2 →
Q8RW99 — 0.992 Q8RW99 →
P09199 — 0.992 P09199 →
A2RQ29 — 0.992 A2RQ29 →
B7V3K3 — 0.992 B7V3K3 →
Q0SXH4 — 0.992 Q0SXH4 →