Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KCNA1 | Q09470 | 4/20 | 0.39 |
| ▸ | KCNAB1 | Q14722 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APOB | P04114 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922383 | 0.92 | KMT2A (0.41) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL14228358 | 0.91 | KMT2A (0.39) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL9922958 | 0.91 | PTGER3 (0.42) | MEN1KMT2AALDH1A1LMNAKCNA1 | |
| SCHEMBL12177244 | 0.90 | MEN1 (0.39) | MEN1KMT2AALDH1A1LMNAKCNA1 | |
| SCHEMBL9922366 | 0.90 | KMT2A (0.38) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL9922175 | 0.90 | KMT2A (0.38) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL9922950 | 0.90 | KMT2A (0.43) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL12161564 | 0.90 | PTGER1 (0.39) | MEN1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL9922367 | 0.90 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1LMNAKCNA1 | |
| SCHEMBL9922398 | 0.89 | MEN1 (0.40) | MEN1KMT2AALDH1A1LMNARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |