Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 4/20 | 0.33 |
| ▸ | KCNAB1 | Q14722 | 4/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922296 | 0.92 | P2RY12 (0.43) | P2RY12MEN1KMT2AGRM1MAPK14 | |
| SCHEMBL9922378 | 0.88 | MEN1 (0.37) | MEN1KMT2AGRM1GRM4MAPK14 | |
| SCHEMBL9922176 | 0.85 | BRD4 (0.40) | BRD4CREBBPP2RY12MEN1KMT2A | |
| SCHEMBL13638623 | 0.85 | BRD4 (0.39) | BRD4CREBBPP2RY12MEN1KMT2A | |
| SCHEMBL9922574 | 0.85 | BRD4 (0.39) | BRD4CREBBPP2RY12MEN1KMT2A | |
| SCHEMBL9923125 | 0.85 | GRM1 (0.41) | P2RY12MEN1KMT2AGRM1GRM4 | |
| SCHEMBL9922576 | 0.85 | BRD4 (0.39) | BRD4CREBBPP2RY12MEN1KMT2A | |
| SCHEMBL12177059 | 0.83 | P2RY12 (0.39) | BRD4CREBBPP2RY12MEN1KMT2A | |
| SCHEMBL12177057 | 0.83 | P2RY12 (0.42) | BRD4CREBBPP2RY12MEN1KMT2A | |
| SCHEMBL12177060 | 0.82 | BRD4 (0.38) | BRD4CREBBPP2RY12KCNA1KCNAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |