Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KCNA1 | Q09470 | 7/20 | 0.35 |
| ▸ | KCNAB1 | Q14722 | 7/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922302 | 0.91 | P2RY12 (0.41) | KCNA1KCNAB1P2RY12 | |
| SCHEMBL9922176 | 0.88 | BRD4 (0.40) | BRD4CREBBPMEN1KMT2AKCNA1 | |
| SCHEMBL9922574 | 0.88 | BRD4 (0.39) | BRD4CREBBPMEN1KMT2AKCNA1 | |
| SCHEMBL9922576 | 0.88 | BRD4 (0.39) | BRD4CREBBPMEN1KMT2AKCNA1 | |
| SCHEMBL9922180 | 0.87 | KMT2A (0.37) | MEN1KMT2A | |
| SCHEMBL13638622 | 0.85 | BRD4 (0.36) | BRD4CREBBPMEN1KMT2AKCNA1 | |
| SCHEMBL12177060 | 0.84 | BRD4 (0.38) | BRD4CREBBPKCNA1KCNAB1P2RY12 | |
| SCHEMBL13638507 | 0.84 | BRD4 (0.38) | BRD4CREBBPKCNA1KCNAB1P2RY12 | |
| SCHEMBL9923127 | 0.83 | GRM1 (0.40) | KCNA1KCNAB1GRM1P2RY12 | |
| SCHEMBL9922582 | 0.83 | HRH3 (0.37) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |