Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | ITK | Q08881 | 4/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923260 | 0.92 | KIT (0.43) | FBP1NLRP3ITKPRKAB2PRKAG1 | |
| SCHEMBL9922391 | 0.89 | ROCK1 (0.45) | FBP1NLRP3ITKROCK1CHEK1 | |
| SCHEMBL14088508 | 0.85 | MEN1 (0.42) | FBP1NLRP3ITKPRKAB2PRKAG1 | |
| SCHEMBL12161716 | 0.84 | P2RY12 (0.44) | FBP1NLRP3ITKPRKAB2PRKAG1 | |
| SCHEMBL12161694 | 0.81 | ROCK1 (0.44) | FBP1NLRP3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL14228352 | 0.80 | CA12 (0.39) | ITKROCK1NPC1RAB9AMAOB | |
| SCHEMBL9922623 | 0.78 | MEN1 (0.42) | FBP1ITKROCK1CHEK1MAP2K4 | |
| SCHEMBL9922220 | 0.76 | MAPT (0.40) | FBP1NLRP3NPC1MAPTRAB9A | |
| SCHEMBL13633811 | 0.76 | P2RY12 (0.42) | FBP1ITKLRRK2MAPTMEN1 | |
| SCHEMBL9923253 | 0.75 | MAPT (0.41) | FBP1NLRP3PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |