Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 8/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177640 | 0.93 | ESR1 (0.39) | P2RY12ESR1ESR2RAB9ASMN1; SMN2 | |
| SCHEMBL9922141 | 0.92 | P2RY12 (0.48) | P2RY12ESR1ESR2RAB9ASMN1; SMN2 | |
| SCHEMBL13638705 | 0.91 | ATM (0.43) | ATM | |
| SCHEMBL14113551 | 0.89 | HRH3 (0.39) | P2RY12 | |
| SCHEMBL12177093 | 0.89 | P2RY12 (0.37) | P2RY12RAB9ASMN1; SMN2NPC1ATM | |
| SCHEMBL14113771 | 0.88 | ESR1 (0.36) | P2RY12ESR1ESR2RAB9ASMN1; SMN2 | |
| SCHEMBL13638649 | 0.87 | EPHX2 (0.40) | P2RY12SMN1; SMN2ATMLMNA | |
| SCHEMBL14228575 | 0.85 | P2RY12 (0.45) | P2RY12RAB9APPARGLMNACYP1A2 | |
| SCHEMBL9922707 | 0.85 | P2RY12 (0.47) | P2RY12ESR1ESR2RAB9ASMN1; SMN2 | |
| SCHEMBL13638369 | 0.85 | ESR1 (0.38) | P2RY12ESR1ESR2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |