Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14113551 | 0.93 | HRH3 (0.39) | MCHR1P2RY12FLT3 | |
| SCHEMBL9922139 | 0.92 | P2RY12 (0.43) | EPHX2ATMLMNAMAPTSMN1; SMN2 | |
| SCHEMBL14228477 | 0.90 | MET (0.39) | EPHX2LMNAMCHR1USP7P2RY12 | |
| SCHEMBL9922134 | 0.88 | KMT2A (0.47) | EPHX2MAPTSMN1; SMN2P2RY12 | |
| SCHEMBL12177310 | 0.88 | P2RY12 (0.41) | EPHX2LMNAMAPTSMN1; SMN2MCHR1 | |
| SCHEMBL13638647 | 0.87 | P2RY12 (0.39) | ATMLMNASMN1; SMN2P2RY12 | |
| SCHEMBL13182891 | 0.87 | RAD52 (0.40) | SMN1; SMN2 | |
| SCHEMBL12177094 | 0.86 | MET (0.40) | EPHX2SMN1; SMN2FLT3 | |
| SCHEMBL12177640 | 0.85 | ESR1 (0.39) | ATMLMNAMAPTSMN1; SMN2P2RY12 | |
| SCHEMBL9922547 | 0.85 | P2RY12 (0.45) | MCHR1P2RY12CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |