Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | FBP1 | P09467 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14113530 | 0.97 | P2RY12 (0.35) | P2RY12POLBFBP1SMN1; SMN2NPC1 | |
| SCHEMBL9923112 | 0.92 | P2RY12 (0.42) | P2RY12POLBFBP1SMN1; SMN2NPC1 | |
| SCHEMBL9922866 | 0.91 | P2RY12 (0.37) | P2RY12POLBFBP1SMN1; SMN2QPCT | |
| SCHEMBL9922844 | 0.88 | P2RY12 (0.42) | P2RY12FBP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9922864 | 0.88 | P2RY12 (0.37) | P2RY12POLBFBP1SMN1; SMN2QPCT | |
| SCHEMBL12177273 | 0.86 | P2RY12 (0.37) | P2RY12POLBFBP1SMN1; SMN2NPC1 | |
| SCHEMBL14113533 | 0.86 | P2RY12 (0.39) | P2RY12POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14228637 | 0.85 | CHRM5 (0.34) | P2RY12FBP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9922642 | 0.83 | P2RY12 (0.34) | P2RY12POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13182767 | 0.83 | P2RY12 (0.39) | P2RY12POLBFBP1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |