Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.31 |
| ▸ | NPY2R | P49146 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14113770 | 0.86 | P2RY12 (0.37) | P2RY12KDM4EHTTKMT2A | |
| SCHEMBL9923147 | 0.85 | P2RY12 (0.54) | P2RY12KDM4EHTTNPY5RERCC1 | |
| SCHEMBL12177635 | 0.84 | P2RY12 (0.48) | P2RY12KDM4EHTTNPY5RERCC1 | |
| SCHEMBL12177231 | 0.83 | P2RY12 (0.50) | P2RY12KDM4EHTT | |
| SCHEMBL13638508 | 0.79 | P2RY12 (0.33) | P2RY12 | |
| SCHEMBL9922505 | 0.78 | P2RY12 (0.58) | P2RY12ERCC1FEN1ERCC4GCK | |
| SCHEMBL14113677 | 0.77 | P2RY12 (0.44) | P2RY12ERCC1FEN1ERCC4GCK | |
| SCHEMBL12177632 | 0.77 | P2RY12 (0.39) | P2RY12 | |
| SCHEMBL12177237 | 0.75 | P2RY12 (0.49) | P2RY12ERCC1FEN1ERCC4GCK | |
| SCHEMBL9922645 | 0.75 | P2RY12 (0.64) | P2RY12GCKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |