Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 3/20 | 0.36 |
| ▸ | POT1 | Q9NUX5 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14113540 | 0.88 | PPARG (0.40) | HRH3KCNH2PPARGTP53 | |
| SCHEMBL14228334 | 0.87 | TERT (0.39) | HRH3KCNH2TERTPOT1 | |
| SCHEMBL14113710 | 0.86 | PPARG (0.40) | HRH3KCNH2PPARGTP53 | |
| SCHEMBL9922173 | 0.84 | P2RY12 (0.49) | HRH3KCNH2ADRA1ATERTPOT1 | |
| SCHEMBL9922172 | 0.84 | P2RY12 (0.49) | HRH3KCNH2ADRA1ATERTPOT1 | |
| SCHEMBL13182848 | 0.83 | HRH3 (0.40) | HRH3KCNH2ADRA1ATERTPOT1 | |
| SCHEMBL14228338 | 0.82 | TSHR (0.40) | — | |
| SCHEMBL9923217 | 0.81 | HRH3 (0.47) | HRH3KCNH2ADRA1APPARGTERT | |
| SCHEMBL12161445 | 0.80 | P2RY12 (0.51) | HRH3KCNH2ADRA1APPARGTERT | |
| SCHEMBL12177420 | 0.80 | HRH3 (0.46) | HRH3KCNH2ADRA1APPARGTERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |