Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPD | P32754 | 3/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923218 | 0.93 | P2RY12 (0.48) | P2RY12GLAMEN1KMT2AHPD | |
| SCHEMBL12177232 | 0.88 | P2RY12 (0.43) | P2RY12NOD1PPARG | |
| SCHEMBL9923210 | 0.88 | P2RY12 (0.40) | P2RY12GLAMEN1KMT2AHPD | |
| SCHEMBL12177329 | 0.87 | P2RY12 (0.41) | P2RY12GLAMEN1KMT2AHPD | |
| SCHEMBL12177247 | 0.87 | GLA (0.52) | P2RY12GLAHPDNOD1PPARG | |
| SCHEMBL13638586 | 0.87 | P2RY12 (0.40) | P2RY12GLAMEN1KMT2AHPD | |
| SCHEMBL12177248 | 0.86 | P2RY12 (0.40) | P2RY12GLAMEN1KMT2AHPD | |
| SCHEMBL13638708 | 0.86 | P2RY12 (0.40) | P2RY12GLAMEN1KMT2AHPD | |
| SCHEMBL12177306 | 0.85 | KMT2A (0.39) | P2RY12MEN1KMT2ANOD1PPARG | |
| SCHEMBL14113579 | 0.85 | P2RY12 (0.39) | P2RY12GLAMEN1KMT2AHPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |