Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 10/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13982445 | 0.91 | PTGES (0.33) | PTGESCYP3A4 | |
| SCHEMBL13982117 | 0.91 | PTGES (0.33) | PTGESCYP3A4 | |
| SCHEMBL13982455 | 0.91 | CYP1A2 (0.33) | PTGESCYP3A4P2RX7EPHX2 | |
| SCHEMBL13638742 | 0.90 | PTGES (0.33) | PTGESCYP3A4 | |
| SCHEMBL13982374 | 0.89 | PTGES (0.34) | PTGESCYP3A4 | |
| SCHEMBL3806478 | 0.89 | CYP3A4 (0.43) | EPAS1PTGESCYP3A4EPHX2 | |
| SCHEMBL13638728 | 0.89 | PTGES (0.33) | PTGES | |
| SCHEMBL13982371 | 0.88 | PTGES (0.36) | PTGES | |
| SCHEMBL13982342 | 0.87 | PTGES (0.34) | PTGESCYP3A4 | |
| SCHEMBL13982119 | 0.87 | PTGES (0.35) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |