Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638769 | 1.00 | KMT2A (0.37) | KMT2AJAK2JAK1GRM2MAPT | |
| SCHEMBL13634722 | 0.96 | JAK2 (0.34) | KMT2AJAK2JAK1GRM2MAPT | |
| SCHEMBL13634822 | 0.96 | JAK2 (0.34) | KMT2AJAK2JAK1GRM2MAPT | |
| SCHEMBL13270782 | 0.93 | GRM2 (0.33) | KMT2AJAK2JAK1GRM2NAPEPLD | |
| SCHEMBL13638877 | 0.90 | KMT2A (0.38) | KMT2AJAK2JAK1GRM2MAPT | |
| SCHEMBL13270594 | 0.87 | KMT2A (0.37) | KMT2AJAK2JAK1GRM2MAPT | |
| SCHEMBL13634813 | 0.86 | KMT2A (0.41) | KMT2AJAK2JAK1GRM2MAPT | |
| SCHEMBL13634678 | 0.85 | JAK2 (0.35) | KMT2AJAK2JAK1GRM2MAPT | |
| SCHEMBL13638768 | 0.84 | IRAK4 (0.46) | KMT2AIRAK4 | |
| SCHEMBL13638888 | 0.84 | MAPK1 (0.36) | KMT2AJAK2JAK1GRM2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |