Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634822 | 1.00 | JAK2 (0.34) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13638772 | 0.96 | KMT2A (0.37) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13638769 | 0.96 | KMT2A (0.37) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13634678 | 0.90 | JAK2 (0.35) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13270782 | 0.89 | GRM2 (0.33) | JAK2JAK1GRM2KMT2ANAPEPLD | |
| SCHEMBL13634865 | 0.87 | JAK2 (0.36) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13638877 | 0.86 | KMT2A (0.38) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13634868 | 0.85 | JAK2 (0.36) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13634626 | 0.83 | NAPEPLD (0.35) | JAK2JAK1GRM2KMT2AMEN1 | |
| SCHEMBL13270594 | 0.83 | KMT2A (0.37) | JAK2JAK1GRM2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |