Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634720 | 0.92 | IRAK4 (0.47) | IRAK4KMT2AJAK2JAK1MEN1 | |
| SCHEMBL13634721 | 0.90 | IRAK4 (0.49) | IRAK4JAK2JAK1ALDH1A1GRM2 | |
| SCHEMBL13634699 | 0.88 | IRAK4 (0.50) | IRAK4JAK2JAK1GRM2MAPT | |
| SCHEMBL13634550 | 0.87 | IRAK4 (0.46) | IRAK4JAK2JAK1GRM2KDM4E | |
| SCHEMBL13638882 | 0.87 | KMT2A (0.39) | IRAK4KMT2AJAK2JAK1MEN1 | |
| SCHEMBL13638768 | 0.86 | IRAK4 (0.46) | IRAK4KMT2A | |
| SCHEMBL13270594 | 0.85 | KMT2A (0.37) | IRAK4KMT2AJAK2JAK1MEN1 | |
| SCHEMBL13162062 | 0.84 | IRAK4 (0.43) | IRAK4KMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL13634813 | 0.84 | KMT2A (0.41) | IRAK4KMT2AJAK2JAK1MEN1 | |
| SCHEMBL13638913 | 0.84 | IRAK4 (0.49) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |