Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634721 | 0.92 | IRAK4 (0.49) | IRAK4JAK2JAK1GRM2ABCB1 | |
| SCHEMBL13634720 | 0.89 | IRAK4 (0.47) | IRAK4JAK2JAK1GRM2ABCB1 | |
| SCHEMBL13634550 | 0.89 | IRAK4 (0.46) | IRAK4JAK2JAK1GRM2 | |
| SCHEMBL13638816 | 0.88 | IRAK4 (0.46) | IRAK4JAK2JAK1GRM2ABCB1 | |
| SCHEMBL13634784 | 0.86 | IRAK4 (0.51) | IRAK4MAPT | |
| SCHEMBL13634715 | 0.86 | IRAK4 (0.44) | IRAK4JAK2JAK1GRM2MAPT | |
| SCHEMBL13634937 | 0.85 | IRAK4 (0.50) | IRAK4 | |
| SCHEMBL13270469 | 0.82 | IRAK4 (0.47) | IRAK4ACHE | |
| SCHEMBL13634942 | 0.82 | JAK2 (0.39) | IRAK4JAK2JAK1GRM2ACHE | |
| SCHEMBL13270421 | 0.80 | IRAK4 (0.45) | IRAK4JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |